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Chemical Structure : LEI-105
Catalog No.: PC-62857Not For Human Use, Lab Use Only.
LEI-105 (LEI 105) is a potent, highly selective, and reversible dual DAGL-α/DAGL-β inhibitor with pIC50 of 7.5/7.4 respectively.
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LEI-105 (LEI 105) is a potent, highly selective, and reversible dual DAGL-α/DAGL-β inhibitor with pIC50 of 7.5/7.4 respectively.
LEI-105 shows no activity against other enzymes involved in endocannabinoid metabolism (ABHD6, ABHD12, MAGL, or FAAH), and no affinity for CB1 receptor.
LEI-105 concentration-dependently reduces 2-AG levels, but not anandamide levels, in Neuro2A cells.
LEI-105 reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model.
| M.Wt | 384.479 | |
| Formula | C25H24N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Baggelaar MP, et al. J Am Chem Soc. 2015 Jul 15;137(27):8851-7.
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