LEI-105 |CAS:1800327-36-9 Probechem Biochemicals

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Chemical Structure : LEI-105

LEI-105 (LEI105)

Catalog No.: PC-62857Not For Human Use, Lab Use Only.

LEI-105 (LEI 105) is a potent, highly selective, and reversible dual DAGL-α/DAGL-β inhibitor with pIC50 of 7.5/7.4 respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LEI-105 (LEI 105) is a potent, highly selective, and reversible dual DAGL-α/DAGL-β inhibitor with pIC50 of 7.5/7.4 respectively.
LEI-105 shows no activity against other enzymes involved in endocannabinoid metabolism (ABHD6, ABHD12, MAGL, or FAAH), and no affinity for CB1 receptor.
LEI-105 concentration-dependently reduces 2-AG levels, but not anandamide levels, in Neuro2A cells.
LEI-105 reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model.

Physicochemical Properties

M.Wt	384.479
Formula	C25H24N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Phenyl-1-(6-(p-tolyl)oxazolo[4,5-b]pyridin-2-yl)hexan-1-one

References

1. Baggelaar MP, et al. J Am Chem Soc. 2015 Jul 15;137(27):8851-7.

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LEI-105 (LEI105)

Biological Activity

Physicochemical Properties

References

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