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Chemical Structure : LEI-401
CAS No.: 2393840-15-6
Catalog No.: PC-38219Not For Human Use, Lab Use Only.
LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM.
LEI-401 does not inhibit enzymes involved in the biosynthesis and degradation of the other endocannabinoid 2-AG, DAGLα or DAGLβ, MAGL and α,β-hydrolase domain 6 (ABHD6).
LEI-401 reduced NAE levels in neuroblastoma cells and in the brain of freely moving mice, but not in NAPE-PLD KO cells and mice, respectively.
LEI-401 activated the hypothalamus-pituitary-adrenal (HPA) axis and impaired extinction of an aversive memory in mice, thereby mimicking the effects of cannabinoid CB1 receptor antagonism.
| M.Wt | 421.545 | |
| Formula | C24H31N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide |
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1. Mock ED, et al. Nat Chem Biol. 2020 Jun;16(6):667-675.
2. Mock ED, et al. J Med Chem. 2021 Jan 14;64(1):481-515.
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