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LEI-401

Chemical Structure : LEI-401

CAS No.: 2393840-15-6

LEI-401 (LEI401)

Catalog No.: PC-38219Not For Human Use, Lab Use Only.

LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM.

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Biological Activity

LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM.
LEI-401 does not inhibit enzymes involved in the biosynthesis and degradation of the other endocannabinoid 2-AG, DAGLα or DAGLβ, MAGL and α,β-hydrolase domain 6 (ABHD6).
LEI-401 reduced NAE levels in neuroblastoma cells and in the brain of freely moving mice, but not in NAPE-PLD KO cells and mice, respectively.
LEI-401 activated the hypothalamus-pituitary-adrenal (HPA) axis and impaired extinction of an aversive memory in mice, thereby mimicking the effects of cannabinoid CB1 receptor antagonism.

Physicochemical Properties

M.Wt 421.545
Formula C24H31N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide

References

1. Mock ED, et al. Nat Chem Biol. 2020 Jun;16(6):667-675. 

2. Mock ED, et al. J Med Chem. 2021 Jan 14;64(1):481-515.

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