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Chemical Structure : LEI-800
Catalog No.: PC-22556Not For Human Use, Lab Use Only.
LEI-800 is potent antibacterial as an allosteric bacterial topoisomerase DNA gyrase inhibitor with MIC of 3.1 uM and 6.25 uM for E. coli and K. pneumoniae respectively, inhibits the ATP-dependent supercoiling activity of recombinant E. coli DNA gyrase in a gel-based assay with IC50 of 35 nM.
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LEI-800 is potent antibacterial as an allosteric bacterial topoisomerase DNA gyrase inhibitor with MIC of 3.1 uM and 6.25 uM for E. coli and K. pneumoniae respectively, inhibits the ATP-dependent supercoiling activity of recombinant E. coli DNA gyrase in a gel-based assay with IC50 of 35 nM.
LEI-800 shows selectivity towards the Gram-negative strains E. coli and K. pneumoniae when tested against a panel of pathogenic bacteria, maintains activity aginst several clinical isolates of E. coli.
LEI-800 directly interacts with DNA gyrase and blocks gyrase-dependent DNA cleavage。
LEI-800 binds a hydrophobic pocket within the GyrA subunit.
LEI-800 is active against fluoroquinolone-resistant clinical isolates.
| M.Wt | 444.55 | |
| Formula | C25H24N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alexander T Bakke, et al. Nat Chem. 2024 Jun 19. doi: 10.1038/s41557-024-01516-x.
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