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Chemical Structure : LEI110
CAS No.: 2313525-90-3
Catalog No.: PC-35979Not For Human Use, Lab Use Only.
LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $568 | In stock | |
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| 100 mg | Get quote |
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LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6).
LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in human HepG2 cells.
LEI110 is a selective pan-inhibitor of the HRASLS-family of thiol hydrolases (i.e. PLA2G16, HRASLS2, RARRES3 and iNAT).
| M.Wt | 456.465 | |
| Formula | C25H23F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-oxo-5-phenyl-N-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethyl)pentanamide |
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1. Zhou J, et al. ACS Chem Biol. 2019 Jan 8. doi: 10.1021/acschembio.8b00969.
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