LEO 29102

Chemical Structure : LEO 29102

Catalog No.: PC-24965Not For Human Use, Lab Use Only.

LEO 29102 is a potent, selective, and soft-drug PDE4 inhibitor with IC50 of 5 nM (PDE4D), inhibits TNFα release from hPBMCs stimulated with LPS with IC50 of 16 nM.

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Biological Activity

LEO 29102 is a potent, selective, and soft-drug PDE4 inhibitor with IC50 of 5 nM (PDE4D), inhibits TNFα release from hPBMCs stimulated with LPS with IC50 of 16 nM.
LEO 29102 shows less than 10% inhibition of PDE1-PDE11 at 1 μM, PDE6 not tested)。
LEO 29102 has properties suitable for patient-friendly formulations giving efficient drug delivery to the skin.

Physicochemical Properties

M.Wt	441.31
Formula	C20H22Cl2N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-(2-(3,5-Dichloropyridin-4-yl)acetyl)-2,3-dimethoxyphenoxy)-N-propylacetamide

References

1. Felding J, et al. J Med Chem. 2014 Jul 24;57(14):5893-903.

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LEO 29102

Biological Activity

Physicochemical Properties

References

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