LH846 | Circadian modulator, CK1δ inhibitor

Chemical Structure : LH846

CAS No.: 639052-78-1

LH846 (LH-846)

Catalog No.: PC-28450Not For Human Use, Lab Use Only.

LH846 is a small molecule modulator of circadian rhythms, inhibits CKIδ (CK1δ) with an IC50 of 290 nM, CKIα with an IC50 of 2.5 μM, CKIε with an IC50 of 1.3 μM and has no effect on CK2, lengthens circadian period.

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25 mg	$98	In stock
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Biological Activity

LH846 is a small molecule modulator of circadian rhythms, inhibits CKIδ (CK1δ) with an IC50 of 290 nM, CKIα with an IC50 of 2.5 μM, CKIε with an IC50 of 1.3 μM and has no effect on CK2, lengthens circadian period.

Physicochemical Properties

M.Wt	316.80
Formula	C16H13ClN2OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide

References

1. Lee JW, et al. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11.

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LH846 (LH-846)

Biological Activity

Physicochemical Properties

References

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