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Chemical Structure : LHF-535
CAS No.: 1450929-77-7
Catalog No.: PC-35909Not For Human Use, Lab Use Only.
LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3 nM。
LHF-535 has sub-nanomolar potency against the viral envelope glycoproteins from all Lassa virus lineages, with the exception of the glycoprotein from the LP strain from lineage I, which was 100-fold less sensitive than that of other strains.
LHF-535 potently inhibited Junín virus, but not Candid#1 in virus-yield reduction assays.
LHF-535 protects mice in a lethal Tacaribe virus model at 10 mg/kg.
| M.Wt | 412.533 | |
| Formula | C27H28N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(Z)-2-(4-(2-(1-(4-isopropoxyphenyl)-1H-benzo[d]imidazol-5-yl)vinyl)phenyl)propan-2-ol |
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1. Madu IG, et al. PLoS Pathog. 2018 Dec 21;14(12):e1007439.
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