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LJ001

Chemical Structure : LJ001

CAS No.: 851305-26-5

LJ001 (LJ-001)

Catalog No.: PC-62050Not For Human Use, Lab Use Only.

LJ001 ((LJ-001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LJ001 ((LJ-001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1.
LJ001 specifically intercalates into viral membranes, irreversibly inactivates virions while leaving functionally intact envelope proteins, and inhibits viral entry at a step after virus binding but before virus-cell fusion.
LJ001 specifically inhibits virus-cell but not cell-cell fusion

Physicochemical Properties

M.Wt 327.42
Formula C17H13NO2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(5Z)-5-[(5-phenylfuran-2-yl)methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one

References

1. Wolf MC, et al. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62.

2. Vigant F, et al. PLoS Pathog. 2013;9(4):e1003297.

3. Balmer BF, et al. J Virol. 2017 Jan 31;91(4). pii: e02181-16.

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