LJH-685 |CAS:1627710-50-2 Probechem Biochemicals

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Chemical Structure : LJH-685

CAS No.: 1627710-50-2

LJH-685 (LJH 685;LJH685)

Catalog No.: PC-45677Not For Human Use, Lab Use Only.

LJH-685 is a potent and specific pan-RSK inhibitor with IC50s of 6 nM,5 nM and 4 nM for RSK1,RSK2 and RSK3 respectively.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$198	In stock
50 mg	$298	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LJH-685 (LJH685) is a potent and specific pan-RSK inhibitor with IC50s of 6 nM,5 nM and 4 nM for RSK1, RSK2 and RSK3 respectively.
LJH-685 (LJH685) inhibts Y-box binding protein-1 (YB-1) Ser102 phosphorylation (EC50=0.2-0.3 uM) in MDA-MB-231 cancer cells.

Physicochemical Properties

M.Wt	381.4185
Formula	C22H21F2N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-

References

1. Jain R, et al. J Med Chem. 2015 Sep 10;58(17):6766-83.

2. Aronchik I, et al. Mol Cancer Res. 2014 May;12(5):803-12.

3. Davies AH, et al. Oncotarget. 2015 Aug 21;6(24):20570-7.

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LJH-685 (LJH 685;LJH685)

Biological Activity

Physicochemical Properties

References

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