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LJI308

Chemical Structure : LJI308

CAS No.: 1627709-94-7

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LJI308 (LJI 308, LJI-308)

Catalog No.: PC-45678Not For Human Use, Lab Use Only.

LJI308 (LJI 308) is a potent and specific pan-RSK inhibitor with IC50s of 6 nM, 4 nM and 13 nM for RSK1, RSK2 and RSK3 respectively.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LJI308 (LJI 308) is a potent and specific pan-RSK inhibitor with IC50s of 6 nM, 4 nM and 13 nM for RSK1, RSK2 and RSK3 respectively.
LJI308 inhibts Y-box binding protein-1 (YB-1) Ser102 phosphorylation (EC50= 0.2-0.3 uM) in MDA-MB-231 cancer cells.

Physicochemical Properties

M.Wt 368.3766
Formula C21H18F2N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-

References

1. Jain R, et al. J Med Chem. 2015 Sep 10;58(17):6766-83.

2. Aronchik I, et al. Mol Cancer Res. 2014 May;12(5):803-12.

3. Davies AH, et al. Oncotarget. 2015 Aug 21;6(24):20570-7.

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