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Chemical Structure : LJI308
CAS No.: 1627709-94-7
Catalog No.: PC-45678Not For Human Use, Lab Use Only.
LJI308 (LJI 308) is a potent and specific pan-RSK inhibitor with IC50s of 6 nM, 4 nM and 13 nM for RSK1, RSK2 and RSK3 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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LJI308 (LJI 308) is a potent and specific pan-RSK inhibitor with IC50s of 6 nM, 4 nM and 13 nM for RSK1, RSK2 and RSK3 respectively.
LJI308 inhibts Y-box binding protein-1 (YB-1) Ser102 phosphorylation (EC50= 0.2-0.3 uM) in MDA-MB-231 cancer cells.
| M.Wt | 368.3766 | |
| Formula | C21H18F2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]- |
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1. Jain R, et al. J Med Chem. 2015 Sep 10;58(17):6766-83.
2. Aronchik I, et al. Mol Cancer Res. 2014 May;12(5):803-12.
3. Davies AH, et al. Oncotarget. 2015 Aug 21;6(24):20570-7.
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