LK01045 | RIPK3 inhibitor | Probechem Biochemicals

Chemical Structure : LK01045

LK01045 (LK-01045)

Catalog No.: PC-24571Not For Human Use, Lab Use Only.

LK01045 is a potent, highly selective inhibitor targeting RIPK3 with IC50 of 16 nM in ADP-Glo assays.

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Biological Activity

LK01045 is a potent, highly selective inhibitor targeting RIPK3 with IC50 of 16 nM in ADP-Glo assays.
LK01045 shows improved inhibition against TNF-α-induced necroptosis in both L929 and HT29 cells, with EC50 values of 0.61 and 0.16 µM, respectively, compared with
LK01045 effectively inhibits RIPK3 and MLKL phosphorylation induced by TNF-α in both L929 and HT29 cells.

Physicochemical Properties

M.Wt	511.66
Formula	C26H29N3O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-((2-cyclopentylbenzo[d]thiazol-5-yl)amino)-6-(isopropylsulfonyl)quinolin-7-yl)oxy)ethan-1-ol

References

1. Su H, et al. Nat Commun. 2025 May 8;16(1):4288.

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LK01045 (LK-01045)

Biological Activity

Physicochemical Properties

References

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