LLC355 | DDR1 degrader | Probechem Biochemicals

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Chemical Structure : LLC355

LLC355 (LLC-355)

Catalog No.: PC-22339Not For Human Use, Lab Use Only.

LLC355 is a potent DDR1 degrader and autophagosome-tethering compound (ATTEC) with DC50 of 150.8 nM in NCI-H23 cells, induce DDR1 degradation via lysosome-mediated autophagy, potently suppresses cancer cell tumorigenicity, migration, and invasion.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	1133.72
Formula	C63H64ClF3N10O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(3-{[4-(2-{2-[(3-{N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamido}propyl)amino]-2-oxoethoxy}ethyl)piperazin-1-yl]methyl}-5-(trifluoromethyl)phenyl)-4-ethyl-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide

References

1. Lianchao Liu, et al. J Med Chem. 2024 May 10. doi: 10.1021/acs.jmedchem.4c00162.

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LLC355 (LLC-355)

Biological Activity

Physicochemical Properties

References

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