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LLP2A

Chemical Structure : LLP2A

CAS No.: 874148-50-2

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LLP2A

Catalog No.: PC-62157Not For Human Use, Lab Use Only.

LLP2A is a high-affinity, selective peptidomimetic ligand of α4β1 integrin with IC50 of 2 pM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LLP2A is a high-affinity, selective peptidomimetic ligand of α4β1 integrin with IC50 of 2 pM.
LLP2A shows no binding affinity for α2β1, α6β1, αLβ2 and αMβ2 integrins.
LLP2A can be used to image α4β1-expressing lymphomas with high sensitivity and specificity when conjugated to a near infrared fluorescent dye in a mouse xenograft model.

Physicochemical Properties

M.Wt 810.953
Formula C43H54N8O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-6-((1-carbamoylcyclohexyl)amino)-6-oxo-5-((S)-6-((E)-3-(pyridin-3-yl)acrylamido)-2-(2-(4-(3-(o-tolyl)ureido)phenyl)acetamido)hexanamido)hexanoic acid

References

1. Peng L, et al. Nat Chem Biol. 2006 Jul;2(7):381-9.

2. Beaino W, et al. J Nucl Med. 2014 Nov;55(11):1856-63.

3. Soodgupta D, et al. J Nucl Med. 2016 Apr;57(4):640-5.

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