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LLP2A

Chemical Structure : LLP2A

CAS No.: 874148-50-2

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LLP2A (α4β1 integrin inhibitor)

Catalog No.: PC-62157Not For Human Use, Lab Use Only.

LLP2A is a high-affinity, selective peptidomimetic ligand of α4β1 integrin with IC50 of 2 pM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LLP2A is a high-affinity, selective peptidomimetic ligand of α4β1 integrin with IC50 of 2 pM.
    LLP2A shows no binding affinity for α2β1, α6β1, αLβ2 and αMβ2 integrins.
    LLP2A can be used to image α4β1-expressing lymphomas with high sensitivity and specificity when conjugated to a near infrared fluorescent dye in a mouse xenograft model.

    Physicochemical Properties

    M.Wt 810.953
    Formula C43H54N8O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-6-((1-carbamoylcyclohexyl)amino)-6-oxo-5-((S)-6-((E)-3-(pyridin-3-yl)acrylamido)-2-(2-(4-(3-(o-tolyl)ureido)phenyl)acetamido)hexanamido)hexanoic acid

    References

    1. Peng L, et al. Nat Chem Biol. 2006 Jul;2(7):381-9.

    2. Beaino W, et al. J Nucl Med. 2014 Nov;55(11):1856-63.

    3. Soodgupta D, et al. J Nucl Med. 2016 Apr;57(4):640-5.

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