Catalog No.: PC-61490Not For Human Use, Lab Use Only.
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
LM11A-31 is an orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
LM11A-31 shows no effect on nerve growth factor (NGF) binding to TrkA.
LM11A-31 prevents and reverses atrophy of cholinergic neurites, as well as reversing AD pathologies in mid- to late-stage AD mice models.
