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LM11A-31

Chemical Structure : LM11A-31

CAS No.: 102562-74-3

LM11A-31 (LM11A 31)

Catalog No.: PC-61490Not For Human Use, Lab Use Only.

An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LM11A-31 is an orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
LM11A-31 shows no effect on nerve growth factor (NGF) binding to TrkA.
LM11A-31 prevents and reverses atrophy of cholinergic neurites, as well as reversing AD pathologies in mid- to late-stage AD mice models.

Physicochemical Properties

M.Wt 243.351
Formula C12H25N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide

References

1. Massa SM, et al. J Neurosci. 2006 May 17;26(20):5288-300.

2. Meeker RB, et al. J Neuroimmune Pharmacol. 2012 Jun;7(2):388-400.

3. Simmons DA, et al. PLoS One. 2014 Aug 25;9(8):e102136.

4. Meeker RB, et al. Exp Neurol. 2016 Jan;275 Pt 1:182-98.

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