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Chemical Structure : LM11A-31 dihydrochloride
CAS No.: 1243259-19-9
Catalog No.: PC-61489Not For Human Use, Lab Use Only.
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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LM11A-31 dihydrochloride is an orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
LM11A-31 shows no effect on nerve growth factor (NGF) binding to TrkA.
LM11A-31 prevents and reverses atrophy of cholinergic neurites, as well as reversing AD pathologies in mid- to late-stage AD mice models.
| M.Wt | 316.27 | |
| Formula | C12H25N3O2.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2S,3S)-2-amino-3-methyl-N-(2-morpholinoethyl)pentanamide dihydrochloride |
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1. Massa SM, et al. J Neurosci. 2006 May 17;26(20):5288-300.
2. Meeker RB, et al. J Neuroimmune Pharmacol. 2012 Jun;7(2):388-400.
3. Simmons DA, et al. PLoS One. 2014 Aug 25;9(8):e102136.
4. Meeker RB, et al. Exp Neurol. 2016 Jan;275 Pt 1:182-98.
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