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Chemical Structure : LM22B-10
CAS No.: 342777-54-2
Catalog No.: PC-22385Not For Human Use, Lab Use Only.
LM22B-10 is a small moelcule agonist neurotrophin (NT) receptor TrkB and TrkC, selectively binds to and activates TrkB as well as TrkC, shows neurotrophic activitie.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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LM22B-10 is a small moelcule agonist neurotrophin (NT) receptor TrkB and TrkC, selectively binds to and activates TrkB as well as TrkC, shows neurotrophic activitie.
LM22B-10 binds to TrkB-Fc and TrkC-Fc in a dose-dependent manner, but not TrkA-Fc or p75NTR-Fc, displaces BDNF from TrkB and NT-3 from TrkC.
LM22B-10 promotes cell survival preferentially through TrkB and TrkC. LM22B-10, but not BDNF or NT-3, promotes neurite outgrowth in an inhibitory environment.
LM22B-10 selectively induces TrkB, TrkC, AKT and ERK phosphorylation in hippocampal neurons in culture.
LM22B-10 (5 mg/kg IN) penetrates the BBB, and induces TrkB and TrkC phosphorylation and downstream signaling in vivo.
| M.Wt | 485.02 | |
| Formula | C27H33ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[4-[[4-[Bis-(2-hydroxy-ethyl)-amino]-phenyl]-(4-chloro-phenyl)-methyl]-phenyl]-(2-hydroxy-ethyl)-amino]-ethanol |
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1. Yang T, et al. Neuropharmacology. 2016 Nov;110(Pt A):343-361.
2. Xiang RL, et al. J Cell Physiol. 2020 Jan;235(1):232-244.
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