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Chemical Structure : LM98
Catalog No.: PC-72427Not For Human Use, Lab Use Only.
LM98 (TEAD inhibitor LM98) is a flufenamic acid analogue, shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity.
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LM98 (TEAD inhibitor LM98) is a flufenamic acid analogue, shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity.
LM98 is anchored within the palmitic acid pocket of TEAD.
LM98 reduces the expression of CTGF and Cyr61, inhibits MDA-MB-231 breast cancer cell migration and arrests cell cycling in the S phase during cell division.
| M.Wt | 315.388 | |
| Formula | C19H22FNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Léa Mélin, et al. ChemMedChem. 2021 Oct 6;16(19):2982-3002.
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