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Chemical Structure : LMK-235
CAS No.: 1418033-25-6
Catalog No.: PC-45595Not For Human Use, Lab Use Only.
LMK-235 (LMK235) is a selective HDAC5 and HDAC4 inhibitor with IC50 of 4.22 nM and 11.9 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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LMK-235 (LMK235) is a selective HDAC5 and HDAC4 inhibitor with IC50 of 4.22 nM and 11.9 nM respectively.
LMK-235 is less potent for HDAC1/11/2/8.
LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 =0.49 and 0.32 uM respectively).
| M.Wt | 294.3462 | |
| Formula | C15H22N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl- |
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1. Marek L, et al. J Med Chem. 2013 Jan 24;56(2):427-36.
2. Li A, et al. Eur J Pain. 2013 Sep;17(8):1156-67.
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