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LMP-420

Chemical Structure : LMP-420

CAS No.: 473870-63-2

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LMP-420 (LMP 420, LMP420)

Catalog No.: PC-61278Not For Human Use, Lab Use Only.

LMP-420 is a small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LMP-420 is a small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells.
    LMP-420 also shows potent cytotoxic effects for CLL cells (ED50=245 nM, 72h) and minimal toxicity for normal hematopoietic cells.
    LMP-420 decreases colonic TNF levels in IL-10-deficient mice with chronic colitis.

    Physicochemical Properties

    M.Wt 283.523
    Formula C10H15BClN5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5-(2-amino-6-chloro-9H-purin-9-yl)pentyl)boronic acid

    References

    1. Haraguchi S, et al. AIDS Res Ther. 2006 Mar 31;3:8.

    2. Hale LP, et al. J Inflamm (Lond). 2008 Mar 10;5:4.

    3. Mowery YM, et al. Leukemia. 2010 Sep;24(9):1580-7.

    4. Angaswamy N, et al. Cell Transplant. 2012;21(6):1285-96.

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