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Chemical Structure : LMP-420
Catalog No.: PC-61278Not For Human Use, Lab Use Only.
A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells.
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A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells; also shows potent cytotoxic effects for CLL cells (ED50=245 nM, 72h) and minimal toxicity for normal hematopoietic cells; decreases colonic TNF levels in IL-10-deficient mice with chronic colitis.
| M.Wt | 283.523 | |
| Formula | C10H15BClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Haraguchi S, et al. AIDS Res Ther. 2006 Mar 31;3:8.
2. Hale LP, et al. J Inflamm (Lond). 2008 Mar 10;5:4.
3. Mowery YM, et al. Leukemia. 2010 Sep;24(9):1580-7.
4. Angaswamy N, et al. Cell Transplant. 2012;21(6):1285-96.
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