LMP517 | TOP1/2 inhibitor | Probechem Biochemicals

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Chemical Structure : LMP517

LMP517 (NSC 781517)

Catalog No.: PC-72441Not For Human Use, Lab Use Only.

LMP517 (NSC 781517) is a non-camptothecin, dual TOP1 and TOP2 topoisomerase inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LMP517 (NSC 781517) is a non-camptothecin, dual TOP1 and TOP2 topoisomerase inhibitor.
LMP517 showed better antitumor activity than its parent compound LMP744 against H82 (small cell lung cancer) xenografts.

Physicochemical Properties

M.Wt	410.401
Formula	C22H19FN2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-fluoro-6-(3-((2-hydroxyethyl)amino)propyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione

References

1. Laetitia Marzi, et al. Mol Cancer Ther. 2020 Aug;19(8):1589-1597.

2. Marzi L, et al. Mol Cancer Ther. 2018 Aug;17(8):1694-1704.

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LMP517 (NSC 781517)

Biological Activity

Physicochemical Properties

References

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