Catalog No.: PC-23782Not For Human Use, Lab Use Only.
LNS8801 is a specific, orally available small molecule agonist of G protein–coupled estrogen receptor-1 (GPER), induces both GPER-dependent and GPER-independent effects and elicits potent anticancer activities in vitro and in vivo.
LNS8801 is a specific, orally available small molecule agonist of G protein–coupled estrogen receptor-1 (GPER), induces both GPER-dependent and GPER-independent effects and elicits potent anticancer activities in vitro and in vivo. LNS8801 induces differentiation markers and inhibits uveal melanoma cell proliferation and migration. LNS8801 induces the formation of defective mitotic spindles and an arrest of the cell cycle in G2–M. LNS8801 has potent antitumor effects in uveal melanoma xenograft.
