LOXO-195 RS-isomer |CAS:2097002-59-8 Probechem Biochemicals

Chemical Structure : LOXO-195 RS-isomer

LOXO-195 RS-isomer (LOXO 195;LOXO195)

Catalog No.: PC-60902Not For Human Use, Lab Use Only.

The RS-isomer of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively..

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Biological Activity

The RS-isomer of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.

Physicochemical Properties

M.Wt	380.427
Formula	C20H21FN6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(13E,14E,22S,6S)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one

References

1. Drilon A, et al. Cancer Discov. 2017 Sep;7(9):963-972.

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LOXO-195 RS-isomer (LOXO 195;LOXO195)

Biological Activity

Physicochemical Properties

References

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