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LOXO-195 R racemate

Chemical Structure : LOXO-195 R racemate

CAS No.: 1350884-56-8

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LOXO-195 R racemate (LOXO 195;LOXO195)

Catalog No.: PC-60903Not For Human Use, Lab Use Only.

The R racemate of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively..

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5 mg $168 In stock
25 mg $328 In stock
50 mg $528 In stock
100 mg $858 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

The R racemate of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.

Physicochemical Properties

M.Wt 380.427
Formula C20H21FN6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO (38 mg/mL)
Chemical Name/SMILES

(13E,14E,22S)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one

References

1. Drilon A, et al. Cancer Discov. 2017 Sep;7(9):963-972.

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