Chemical Structure : LP-184
CAS No.:
924835-67-6
LP-184
(LP184)
Catalog No.: PC-22197Not For Human Use, Lab Use Only.
LP-184 is an acylfulvene alkylating agent, inhibits viability of multiple GBM cell isolates including temozolomide-resistant and MGMT-expressing cells with IC50 of 22-310 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LP-184 is an acylfulvene alkylating agent, inhibits viability of multiple GBM cell isolates including temozolomide-resistant and MGMT-expressing cells with IC50 of 22-310 nM.
LP-184 demonstrated highly potent anticancer activity both in primary NSCLC cell lines and in those originating from brain metastases of primary lung cancers.
LP-184 activity correlated with PTGR1 transcript levels but was independent of mutations in key oncogenes (KRAS and KEAP1) and tumor suppressors (TP53 and STK11).
LP-184 was orders of magnitude more potent in vitro than cisplatin and pemetrexed.
LP-184 is an acylfulvene-derived prodrug activated by the oxidoreductase PTGR1 that alkylates at N3-adenine.
Physicochemical Properties
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M.Wt
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304.35
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Formula
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C16H20N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-1-hydroxy-1-((6'-hydroxy-2',4',6'-trimethyl-7'-oxo-6',7'-dihydrospiro[cyclopropane-1,5'-inden]-3'-yl)methyl)urea
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References
1. Kulkarni A, et al. Cancer Res Commun. 2024 Apr 17. doi: 10.1158/2767-9764.CRC-23-0554.
2. Lal B, et al. Clin Cancer Res. 2023 Oct 13;29(20):4209-4218.
3. Kulkarni A, et al. Oncotarget. 2021 Apr 13;12(8):791-806.
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