Chemical Structure : LP-211
CAS No.:
1052147-86-0
LP-211
(LP211)
Catalog No.: PC-73300Not For Human Use, Lab Use Only.
LP-211 is a potent, selective, and BBB-penetrant 5-HT7 receptor agonist with Ki of 0.58 nM, high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LP-211 is a potent, selective, and brain penetrant 5-HT7 receptor agonist with Ki of 0.58 nM, high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).
LP-211 displays excellent selectivity profile over a panel of 5-HT receptor subtypes.|
LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition.
LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by 5-HT7 antagonist SB-269970.
Physicochemical Properties
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M.Wt
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466.629
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Formula
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C30H34N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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References
1. Hedlund PB, et al. Neurosci Lett. 2010 Aug 30;481(1):12-6.
2. Leopoldo M, et al. J Med Chem. 2008 Sep 25;51(18):5813-22.
3. Speranza L, et al. Neuropharmacology. 2013 Apr;67:155-67.
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