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LP-533401

Chemical Structure : LP-533401

CAS No.: 945976-43-2

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LP-533401 (LP533401)

Catalog No.: PC-28323Not For Human Use, Lab Use Only.

LP-533401 (LP533401) is a potent, peripheral Tryptophan hydroxylase 1 (TPH1) inhibitor, inhibits the rate-limiting step of serotonin (5-HT) synthesis, selectively reduce 5-HT levels in the murine gastrointestinal tract without affecting brain 5-HT levels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LP-533401 (LP533401) is a potent, peripheral Tryptophan hydroxylase 1 (TPH1) inhibitor, inhibits the rate-limiting step of serotonin (5-HT) synthesis, selectively reduce 5-HT levels in the murine gastrointestinal tract without affecting brain 5-HT levels.

Physicochemical Properties

M.Wt 526.49
Formula C27H22F4N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S)-2-Amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid

References

1. Namkung J, et al. Diabetes Metab J. 2018 Jun;42(3):233-243.

2. Liu Q, et al. J Pharmacol Exp Ther. 2008;325:47–55.

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