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Chemical Structure : LP-935509
CAS No.: 1454555-29-3
Catalog No.: PC-60635Not For Human Use, Lab Use Only.
LP-935509 is a potent, selective and brain-penetrant adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 of 3.3 nM.
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|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LP-935509 is a potent, selective and brain-penetrant adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 of 3.3 nM.
LP-935509 inhibited μ2 protein phosphorylation in HEK293 cells overexpressing human AAK1 with IC50 of 2.8 nM.
LP-935509 also potent inhibits closely related BIKE and GAK with IC50 of 14 nM and 320 nM, respectively in a panel of 389 kinases.
LP-935509 reduces pain response in phase II formalin and reverses fully established pain behavior in vivo.
| M.Wt | 396.451 | |
| Formula | C20H24N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
isopropyl 4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate |
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1. Kostich W, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.
2. Louis JV, et al. Neuropharmacology. 2017 May 15;118:167-174.
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