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LPA1 antagonist HL001

Chemical Structure : LPA1 antagonist HL001

CAS No.: 1614824-42-8

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LPA1 antagonist HL001 (HL001)

Catalog No.: PC-21569Not For Human Use, Lab Use Only.

HL001 is a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, suppresses fibrosis-associated subpopulations of fibroblasts, exhibits significant anti-fibrotic effects both in murine models and human organoid models.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HL001 is a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, suppresses fibrosis-associated subpopulations of fibroblasts, exhibits significant anti-fibrotic effects both in murine models and human organoid models.

    Physicochemical Properties

    M.Wt 548.05
    Formula C30H26ClNO5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(4'-(5-chloro-3-(((1-phenylethoxy)carbonyl)amino)thiophen-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

    References

    1. Yuki Yamamoto, et al. European Respiratory Journal 2023 62: OA898.

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