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Chemical Structure : LPD-01
Catalog No.: PC-21819Not For Human Use, Lab Use Only.
LPD-01 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway, directly binds to importin7, inhibits the transactivation of target genes of the Wnt/β-catenin signaling pathway.
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LPD-01 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway, directly binds to importin7, inhibits the transactivation of target genes of the Wnt/β-catenin signaling pathway.
LPD-01 inhibits the Wnt/β-catenin signaling pathway without affecting β-catenin.
Importin7 is a member of the importin-βfamily of proteins of nuclear transport receptors that can act autonomously or in association with importin-β1.
LPD-01 inhibits the cell growth of human colorectal cancer cells with IC50 of 10.3 uM and 27.24 uM for HT-29 and SW480 cells, respectively.
LPD-01 reduces the expression of the target genes of the Wnt/β-catenin signaling pathway.
LPD-01 inhibits the nuclear translocation of importin7 cargoes such as Smad2 and Smad3 in TGF-β-stimulated HT-29 cells, and the knockdown of importin7 reduces the expression of the target genes of the Wnt/β-catenin signaling pathway.
| M.Wt | 350.46 | |
| Formula | C23H26O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takahiro Kitagawa, et al. J Nat Med. 2024 Jan 24. doi: 10.1007/s11418-023-01774-y.
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