Chemical Structure : LPD-01
CAS No.:
2734880-08-9
LPD-01
Catalog No.: PC-21819Not For Human Use, Lab Use Only.
LPD-01 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway, directly binds to importin7, inhibits the transactivation of target genes of the Wnt/β-catenin signaling pathway.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LPD-01 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway, directly binds to importin7, inhibits the transactivation of target genes of the Wnt/β-catenin signaling pathway.
LPD-01 inhibits the Wnt/β-catenin signaling pathway without affecting β-catenin.
Importin7 is a member of the importin-βfamily of proteins of nuclear transport receptors that can act autonomously or in association with importin-β1.
LPD-01 inhibits the cell growth of human colorectal cancer cells with IC50 of 10.3 uM and 27.24 uM for HT-29 and SW480 cells, respectively.
LPD-01 reduces the expression of the target genes of the Wnt/β-catenin signaling pathway.
LPD-01 inhibits the nuclear translocation of importin7 cargoes such as Smad2 and Smad3 in TGF-β-stimulated HT-29 cells, and the knockdown of importin7 reduces the expression of the target genes of the Wnt/β-catenin signaling pathway.
Physicochemical Properties
|
M.Wt
|
350.46
|
|
Formula
|
C23H26O3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(2S,5R,6S)-5-isopropyl-2-methyl-9-((E)-styryl)-3,4,5,6-tetrahydro-2H,7H-2,6-methanopyrano[4,3-b]oxocin-7-one
|
References
1. Takahiro Kitagawa, et al. J Nat Med. 2024 Jan 24. doi: 10.1007/s11418-023-01774-y.
Contact Us
sales@probechem.com
