Chemical Structure : LPM4870108
CAS No.:
2803679-07-2
LPM4870108
(LPM-4870108)
Catalog No.: PC-25354Not For Human Use, Lab Use Only.
LPM4870108 is a next‐generation, potent pan-Trk inhibitor with IC50 of 0.2 nM, 2.4 nM, 3.5 nM and 2.3 nM for TrkC, TrkA, TrkAG595R and TrkAG667C, respectively, shows high selectivity over ALK (IC50=182 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LPM4870108 is a next‐generation, potent pan-Trk inhibitor with IC50 of 0.2 nM, 2.4 nM, 3.5 nM and 2.3 nM for TrkC, TrkA, TrkAG595R and TrkAG667C, respectively, shows high selectivity over ALK (IC50=182 nM).
LPM4870108 (5, 10, or 20 mg/kg) produced significant inhibition of tumor growth both in wild-type NTRK fusion mutation cells (Ba/F3 LMNA-NTRK1cells and Ba/F3 ETV6-NTRK3 cells) and drug-resistant mutation cells (Ba/F3 ETV6-NTRK3-G623R cells and Ba/F3 LMNA-NTRK1-G595R).
LPM4870108 is more efficacious and safer against tumor growth than LOXO-195.
Physicochemical Properties
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M.Wt
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410.41
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Formula
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C20H19FN6O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S,3'E,4'E)-5'-fluorospiro[cyclopropane-1,6'-4-oxa-7-aza-2(4,3)-morpholina-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridinacyclooctaphan]-8'-one
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References
1. Liu B, et al. J Clin Invest. 2025 Aug 12:e194879.
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