Chemical Structure : LQFM215
CAS No.:
LQFM215
(LQFM-215)
Catalog No.: PC-21191Not For Human Use, Lab Use Only.
LQFM215 (LQFM-215) is a synthetic L-proline transporter (PROT/SLC6A7) inhibitor, inhibits proline uptake in hippocampal synaptosome with IC50 of 20.4 uM, present neuroprotective potential.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LQFM215 (LQFM-215) is a synthetic L-proline transporter (PROT/SLC6A7) inhibitor, inhibits proline uptake in hippocampal synaptosome with IC50 of 20.4 uM, present neuroprotective potential.
LQFM215 (10.0 mg/kg) reduces animal motility, without inducing anxious, depressive behaviors, or cognitive impairments, evaluated in the open-field test in mice.
LQFM215 (10.0 mg/kg) prevents an increase in infarction area and motor impairments in the MCAO model, reduces infarction area and motor impairments in the MCAO model.
Physicochemical Properties
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M.Wt
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394.56
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Formula
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C25H34N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3,5-di-tert-butyl-4-hydroxyphenyl)(4-phenylpiperazin-1-yl)methanone
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References
1. Carvalho GA, et al. Pharmacol Rep. 2023 Apr;75(2):276-292.
2. Carvalho GA, et al. Neurochem Res. 2023 Sep 9. doi: 10.1007/s11064-023-04018-3.
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