Chemical Structure : LQFM275
CAS No.:
2755916-95-9
LQFM275
(LQFM-275)
Catalog No.: PC-23807Not For Human Use, Lab Use Only.
LQFM275 is a dual COX-2 and 5-LOX inhibitor with IC50 of 81 and 167 μM respectively, also inhibits myeloperoxidase (MPO) activity, exhibits anti-inflammatory and antinociceptive effects.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LQFM275 is a dual COX-2 and 5-LOX inhibitor with IC50 of 81 and 167 μM respectively, also inhibits myeloperoxidase (MPO) activity, exhibits anti-inflammatory and antinociceptive effects.
LQFM275 prevents the inflammatory damage caused by lipopolysaccharide (LPS) in endothelial cells.
LQFM275 reduces the nociception and hypernociception induced by carrageenan and LPS.
LQFM275 inhibits COX-2/5-LOX and myeloperoxidase (MPO) activity, thus reducing the inflammatory response.
LQFM275 treatment induces the mitigation of pro-inflammatory mediators while increasing anti-inflammatory cytokine levels.
Physicochemical Properties
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M.Wt
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390.54
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Formula
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C21H30N2O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-((3,5-di-tert-butyl-4-hydroxybenzyl)amino)benzenesulfonamide
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References
1. Turones LC, et al. Int Immunopharmacol. 2024 Dec 21;146:113901.
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