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Chemical Structure : LS-102
CAS No.: 1456891-34-1
Catalog No.: PC-22133Not For Human Use, Lab Use Only.
LS-102 is a selective small molecule inhibitor of E3 ubiquitin ligase Synoviolin (SYVN1), inhibits the autoubiquitination of synoviolin with IC50 of 35 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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LS-102 is a selective small molecule inhibitor of E3 ubiquitin ligase Synoviolin (SYVN1), inhibits the autoubiquitination of synoviolin with IC50 of 35 uM.
LS-102 does not inhibit the activity of other E3 ubiquitin ligases, including ARIH1, breast cancer 1 gene (BRCA1)/BRCA1-associated RING domain 1 (BARD1), and estrogen-responsive RING-finger protein (Efp).
LS-102 suppressed the proliferation of rheumatoid synovial cells with IC50 of 5.4 uM.
LS-102 significantly reduced the severity of disease in a mouse model of rheumatoid arthritis (RA).
LS-102 treament increased Drp1 levels and exacerbated the degeneration of GCs in the PCOS rat model.
| M.Wt | 452.61 | |
| Formula | C24H36N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-N2-(Benzo[d]oxazol-6-yl)-N4-(1-cyclohexylethyl)-N6-ethyl-N6-(2-(ethylamino)ethyl)-1,3,5-triazine-2,4,6-triamine |
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1. Fujita H, et al. Mol Med Rep. 2018 Dec;18(6):5701-5708.
2. Yagishita N, et al. Int J Mol Med. 2012 Dec;30(6):1281-6.
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