LSN3172176 | M1 mAChR agonist | Probechem Biochemicals

Chemical Structure : LSN3172176

CAS No.: 3033820-85-5

LSN3172176 (LSN-3172176)

Catalog No.: PC-63443Not For Human Use, Lab Use Only.

LSN3172176 is a potent, selectiive M1 mAChR partial agonist (EC50 2.4-7.0nM, Emax 43%-73%), shows binding selectivity for M1 mAChRs (Kd=1.5 nM).

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Biological Activity

LSN3172176 is a potent, selectiive M1 mAChR partial agonist (EC50 2.4-7.0nM, Emax 43%-73%), shows binding selectivity for M1 mAChRs (Kd=1.5 nM).
LSN3172176 is a potential PET tracer for assessment of M1 mAChR target engagement in the clinic and to further elucidate the function of M1 mAChRs in health and disease.

Physicochemical Properties

M.Wt	385.508
Formula	C22H31N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-(6-methyl-2-oxoindolin-1-yl)-[1,4'-bipiperidine]-1'-carboxylate

References

1. Mogg AJ, et al. J Pharmacol Exp Ther. 2018 Apr 11. pii: jpet.117.246454.

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LSN3172176 (LSN-3172176)

Biological Activity

Physicochemical Properties

References

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