LT-1339-553

Chemical Structure : LT-1339-553

Catalog No.: PC-26869Not For Human Use, Lab Use Only.

LT-1339-553 is a potent, selective and oral bioavailable RIPK1 inhibitor with IC50 of 4.32 nM, cellular antinecroptotic activity (EC50=14.43 nM).

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Biological Activity

LT-1339-553 is a potent, selective and oral bioavailable RIPK1 inhibitor with IC50 of 4.32 nM, cellular antinecroptotic activity (EC50=14.43 nM).
LT-1339-553 significantly alleviates liver injury, inflammation, and collagen deposition in murine model of hepatic fibrosis.
LT-1339-553 suppresses the AKT/PI3K/NF-κB and IL-17 pathways.

Physicochemical Properties

M.Wt	464.35
Formula	C21H13F5N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3-aminobenzo[d]isoxazol-4-yl)-2,3-difluorophenyl)-3-(3-(trifluoromethoxy)phenyl)urea

References

1. Lu JL, et al. J Med Chem. 2026 May 16. doi: 10.1021/acs.jmedchem.5c03775.

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LT-1339-553

Biological Activity

Physicochemical Properties

References

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