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Chemical Structure : LUF7346
Catalog No.: PC-63511Not For Human Use, Lab Use Only.
LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation.
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LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation.
LUF7346 rescues the genetic form of LQTS, reverses drug-induced LQTS and correct thes combination of genetic and drug-induced LQTS.
LUF7346 normalises both action- and field potentials (AP and FP, respectively) in all hPSC-CMs by slowing IKr deactivation and positively shifting the IKr inactivation.
| M.Wt | 411.255 | |
| Formula | C20H15BrN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sala L, et al. EMBO Mol Med. 2016 Sep 1;8(9):1065-81.
2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9.
3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439.
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