Chemical Structure : LW1646
CAS No.:
2306324-65-0
LW1646
(LW-1646)
Catalog No.: PC-27748Not For Human Use, Lab Use Only.
LW1646 is a potent, selective and orally available PDE5 inhibitor with IC50 of 1.09 nM, exerts antifibrotic effects.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LW1646 is a potent, selective and orally available PDE5 inhibitor with IC50 of 1.09 nM, exerts antifibrotic effects.
LW1646 alleviated ER stress and pro-fibrotic responses in HK-2 cells via activating cGMP signaling.
LW1646 showed a stronger ability than sildenafil to promote VASP Ser239 phosphorylation.
LW1646 markedly decreased the expression of these fibrosis-associated proteins.
LW1646 preserved mitochondrial biogenesis and membrane potential.
LW1646 improved mitochondrial dynamics disturbance and oxidative stress induced by TGF-β1 in HK-2 cells.
LW1646 relieved 7UUO-induced renal fibrosis in mice via inhibiting ER stress and maintaining mitochondrial homeostasis.
LW1646 alleviated mitochondrial Ca2+ overload induced by ER stress under pro-fibrotic conditions.
Physicochemical Properties
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M.Wt
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416.45
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Formula
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C23H16N2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(benzo[d][1,3]dioxol-5-ylmethyl)-7-methyl-1-(thiazol-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one
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References
1. Wang M, et al. Free Radic Biol Med. 2026 Aug 19:S0891-5849(26)01040-3.
2. Patent CN109134481 A 2019-01-04.
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