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Chemical Structure : LX-1031
CAS No.: 945976-76-1
Catalog No.: PC-43351Not For Human Use, Lab Use Only.
LX-1031 is a potent, orally active tryptophan 5-hydroxylase (TPH) inhibitor with potency of 10-100 nM, reduces 5-HT synthesis peripherally.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LX-1031 is a potent, orally active tryptophan 5-hydroxylase (TPH) inhibitor with potency of 10-100 nM, reduces 5-HT synthesis peripherally.
LX-1031 dose-dependently reduces expression of 5-HT in the duodenum, jejunum and ileum, but had no effect on brain 5-HT levels.
LX-1031 significantly reduces urinary 5-hydroxyindoleacetic acid (5-HIAA) in vivo.
LX-1031 exhibits potential for illnesses characterized by excess 5-HT, such as diarrhea-predominant irritable bowel syndrome (IBS-D) and carcinoid diarrhea.
| M.Wt | 538.5177 | |
| Formula | C28H25F3N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
L-Phenylalanine, 4-[2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-methoxy[1,1'-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]- |
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1. Camilleri M. IDrugs. 2010 Dec;13(12):921-8.
2. Camilleri M. Neurogastroenterol Motil. 2011 Mar;23(3):193-200.
3. Brown PM, et al. Gastroenterology. 2011 Aug;141(2):507-16.
4. Shi ZC, et al. J Med Chem. 2008 Jul 10;51(13):3684-7.
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