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Chemical Structure : LXH-3-71
Catalog No.: PC-23184Not For Human Use, Lab Use Only.
LXH-3-71 is a potent mlecular glue triggers degradation of 3-phosphoglycerate dehydrogenase (PHGDH), covalently binds to Cys281 of PHGDH, triggers significant and selective degradation of PHGDH both in vitro and in vivo.
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LXH-3-71 is a potent mlecular glue triggers degradation of 3-phosphoglycerate dehydrogenase (PHGDH), covalently binds to Cys281 of PHGDH, triggers significant and selective degradation of PHGDH both in vitro and in vivo.
LXH-3-71 modulates the stemness of colorectal cancer cells (CRCs) both in vitro and in vivo.
LXH-3-71 inhibits the growth of both colorectal cancer cells and colorectal cancer stem cells in vitro.
LXH-3-71 remarkably inhibits the growth and metathesis of mCRCs in vivo.
LXH-3-71 substantially induces the formation of a dynamic complex between PHGDH and DDB1-CUL4 ubiquitin ligase, consequently facilitating the efficient cellular proteasomal degradation of PHGDH.
| M.Wt | 657.94 | |
| Formula | C41H59N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ziqi Huang, et al. Acta Pharm Sin B. 2024 Sep;14(9):4001-4013.
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