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LXRβ agonist 17

Chemical Structure : LXRβ agonist 17

CAS No.: 1878259-00-7

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LXRβ agonist 17

Catalog No.: PC-61598Not For Human Use, Lab Use Only.

LXRβ agonist 17 is a potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LXRβ agonist 17 is a potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα.
    LXRβ agonist 17 also exhibits excellent selectivity against other nuclear hormone receptors (>3,000-fold).
    LXRβ agonist 17 induces the expression of LXR target genes in vitro and in vivo.

    Physicochemical Properties

    M.Wt 488.526
    Formula C21H27F3N4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-(2-(4-(4-(Hydroxymethyl)-3-(methylsulfonyl)phenyl)-2-isopropylpiperazin-1-yl)-4-(trifluoromethyl)pyrimidin-5-yl)methanol

    References

    1. Zheng Y, et al. J Med Chem. 2016 Apr 14;59(7):3264-71.

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