Chemical Structure : LXRβ agonist CL2-57
CAS No.:
2839627-57-3
LXRβ agonist CL2-57
Catalog No.: PC-49757Not For Human Use, Lab Use Only.
LXRβ agonist CL2-57 is a non-lipogenic ABCA1 inducer and an LXRβ-selective agonist (EC50=1.3 uM) and PPAR/RXR antagonist.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LXRβ agonist CL2-57 is a non-lipogenic ABCA1 inducer and an LXRβ-selective agonist (EC50=1.3 uM) and PPAR/RXR antagonist.
CL2-57 enhances ABCA1-linked luciferase activity in HepG2 liver cells (Emax=250%; EC50=1.8 uM).
CL2-57 selectively induces ABCA1 and lessens inflammation in vitro, CL2-57 dose-dependently increased cholesterol efflux from macrophages to apoA1, the primary acceptor of cholesterol from ABCA1 in vivo.
CL2-57 (10 mg/kg oral gavage) enhances glucose tolerance and insulin sensitivity in mice fed a high-fat diet (HFD).
CL2-57 reduces HFD-induced adiposity and alterations in liver gene expression, also reduces gluconeogenic metabolite, broadly attenuated pro-inflammatory cytokines, enzymes, and metabolites in HFD mice.
Physicochemical Properties
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M.Wt
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539.01
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Formula
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C23H23ClN2O7S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(5-chloro-3-(N-(3,4-diethoxyphenyl)-N-methylsulfamoyl)thiophene-2-carboxamido)benzoic acid
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References
1. Cutler T Lewandowski, et al. EBioMedicine. 2021 Apr;66:103287.
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