Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LY-2584702 hydrochloride
Catalog No.: PC-43060Not For Human Use, Lab Use Only.
LY2584702 is a potent, selective, ATP-competitive inhibitor of P70S6 kinase-1 (p70S6K1) with IC50 of 4 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LY-2584702 hydrochloride is a potent, selective, ATP-competitive inhibitor of P70S6 kinase-1 (p70S6K1) with IC50 of 4 nM.
LY-2584702 blocks phosphorylation of p70S6K in primary rat hepatocytes without affecting the phosphorylation of other signaling kinases, including GSK-3β and ERK1/2.
LY-2584702 inhibits phosphorylation of p70S6K in HCT116 colon cancer cells with IC50 of 0.1-0.24 uM, demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.
| M.Wt | 481.877 | |
| Formula | C21H20ClF4N7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Estridge TB, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):108-118.
2. Tolcher A, et al. Eur J Cancer. 2014 Mar;50(5):867-75.
3. Hollebecque A, et al. Eur J Cancer. 2014 Mar;50(5):876-84.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
