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Chemical Structure : LY-404187
CAS No.: 211311-95-4
Catalog No.: PC-61724Not For Human Use, Lab Use Only.
LY-404187 is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 1.3 uM.
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|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
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| 100 mg | Get quote |
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LY-404187 is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 1.3 uM.
LY-404187 selectively enhances glutamate-evoked currents through AMPA receptor/channels of acutely isolated pyramidal neurons.
LY-404187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, Parkinson's disease and ADHD.
| M.Wt | 342.45 | |
| Formula | C19H22N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide |
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1. Baumbarger PJ, et al. J Pharmacol Exp Ther. 2001 Jul;298(1):86-102.
2. Miu P, et al. Neuropharmacology. 2001 Jun;40(8):976-83.
3. O'Neill MJ, et al. Eur J Pharmacol. 2004 Feb 20;486(2):163-74.
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