LY-411575 is a potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines.
LY-411575 dose dependently reduces Aβ(1-40) and Aβ(1-42) in the brain, CSF, and plasma of Tg2576 mice.
LY-411575 reduces cortical Abeta(40) in young transgenic CRND8 mice with ED50 of 0.6 mg/kg, and produces significant thymus atrophy and intestinal goblet cell hyperplasia at higher doses (>3 mg/kg).
