Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LY-411575
CAS No.: 209984-57-6
Catalog No.: PC-45860Not For Human Use, Lab Use Only.
A potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158.4 | In stock | |
| 50 mg | $472 | In stock | |
| 100 mg | $768 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines; dose dependently reduces Aβ(1-40) and Aβ(1-42) in the brain, CSF, and plasma of Tg2576 mice; reduces cortical Abeta(40) in young transgenic CRND8 mice with ED50 of 0.6 mg/kg, and produces significant thymus atrophy and intestinal goblet cell hyperplasia at higher doses (>3 mg/kg).
Alzheimer's Disease
Preclinical
| M.Wt | 479.4753 | |
| Formula | C26H23F2N3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-.alpha.-hydroxy-, (.alpha.S)- |
|
1. Lanz TA, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):49-55.
2. Best JD, et al. J Pharmacol Exp Ther. 2005 May;313(2):902-8.
3. Hyde LA, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1133-43.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
