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Chemical Structure : LY-503430
Catalog No.: PC-61722Not For Human Use, Lab Use Only.
LY-503430 is a novel AMPA receptor (AMPAR) potentiator that selectively enhances glutamate-induced calcium influx into HEK293 cells transfected with human GLUA1, GLUA2, GLUA3, or GLUA4 AMPA receptors with EC50 of 0.1-4 uM.
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LY-503430 is a novel AMPA receptor (AMPAR) potentiator that selectively enhances glutamate-induced calcium influx into HEK293 cells transfected with human GLUA1, GLUA2, GLUA3, or GLUA4 AMPA receptors with EC50 of 0.1-4 uM.
LY-503430 produces both nootropic and neuroprotective effects, reduces brain damage caused by 6-hydroxydopamine or MPTP and also increases levels of the neurotrophic factor BDNF in rat brain; orally active.
| M.Wt | 392.49 | |
| Formula | C20H25FN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Murray TK, et al. J Pharmacol Exp Ther. 2003 Aug;306(2):752-62.
2. O'Neill MJ, et al. CNS Drug Rev. 2005 Spring;11(1):77-96.
3. Ryder JW, et al. J Pharmacol Exp Ther. 2006 Oct;319(1):293-8.
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