LY-83583 (LY83583) is an inhibitor of soluble guanylate cyclase (sGC) and of cGMP production, inhibits sGC in human platelets with IC50 of 2 uM.
LY-83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 uM.
LY-83583 is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with Ki of 3 uM.
Physicochemical Properties
M.Wt
250.3
Formula
C15H10N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6-(phenylamino)-5,8-quinolinedione
References
1. Butcher RA, et al. Nat Chem Biol. 2006 Feb;2(2):103-9.
2. Mülsch A, et al. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):119-25.
