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Chemical Structure : LY2033298
CAS No.: 886047-13-8
Catalog No.: PC-60328Not For Human Use, Lab Use Only.
LY2033298 (LY-2033298) is a potent, selective, positive allosteric modulator of muscarinic M4 receptors.
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|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
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| 100 mg | Get quote |
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LY2033298 (LY-2033298) is a potent, selective, positive allosteric modulator of muscarinic M4 receptors.
LY2033298 directly potentiates agonist binding while having minimal effects on antagonist binding.
LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms, shows antipsychotic activity in vivo.
| M.Wt | 311.784 | |
| Formula | C13H14ClN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide |
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1. Nawaratne V, et al. Mol Pharmacol. 2008 Oct;74(4):1119-31.
2. Chan WY, et al. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10978-83.
3. Leach K, et al. Neuropsychopharmacology. 2010 Mar;35(4):855-69.
4. Gannon RL, et al. Psychopharmacology (Berl). 2012 Nov;224(2):231-40.
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