Chemical Structure : LY2811376
CAS No.:
1194044-20-6
LY2811376
(LY 2811376, LY-2811376)
Catalog No. : PC-42607Not For Human Use, Lab Use Only.
LY2811376 is potent, orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM in enzyme assays.
Packing Price Stock Quantity 5 mg $118 In stock 0 1 2 3 4 5 10 mg $188 In stock 0 1 2 3 4 5 25 mg $328 In stock 0 1 2 3 4 5 50 mg Get quote 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4260701
Biological Activity
LY2811376 is potent, orally available non-peptidic β-secretase (BACE1 ) inhibitor with IC50 of 239 nM in enzyme assays.
Physicochemical Properties
M.Wt
320.3603
Formula
C15H14F2N4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 31 mg/mL
Chemical Name/SMILES
4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-
References
1. May PC, et al. J Neurosci.
2. Filser S, et al. Biol Psychiatry.
3. Portelius E, et al. Alzheimers Res Ther.
4. Cheret C, et al. EMBO J.
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