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Chemical Structure : LY2811376
CAS No.: 1194044-20-6
Catalog No.: PC-42607Not For Human Use, Lab Use Only.
A potent, orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM in enzyme assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $160 | In stock | |
| 50 mg | $464 | In stock | |
| 100 mg | $720 | In stock |
Bulk size, bulk discount!
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A potent, orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM in enzyme assays; demonstrates ∼10-fold selectivity over BACE2, and >50-fold over aspartyl proteases cathepsin D, pepsin, or renin; produces profound Aβ-lowering effects in vivo.
Alzheimer's Disease
Phase 1 Discontinued
| M.Wt | 320.3603 | |
| Formula | C15H14F2N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)- |
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1. May PC, et al. J Neurosci. 2011 Nov 16;31(46):16507-16.
2. Filser S, et al. Biol Psychiatry. 2015 Apr 15;77(8):729-39.
3. Portelius E, et al. Alzheimers Res Ther. 2014 Nov 17;6(5-8):75.
4. Cheret C, et al. EMBO J. 2013 Jul 17;32(14):2015-28.
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