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Chemical Structure : LY2817412
Catalog No.: PC-21793Not For Human Use, Lab Use Only.
LY2817412 is a potent, selective andorally active nociceptin/orphanin FQ (NOP) receptor antagonist with Ki of 0.176 nM, Kb of 0.273 nM in functional assay of receptor-mediated G-protein activation using [35S]-GTPγS binding.
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LY2817412 is a potent, selective andorally active nociceptin/orphanin FQ (NOP) receptor antagonist with Ki of 0.176 nM, Kb of 0.273 nM in functional assay of receptor-mediated G-protein activation using [35S]-GTPγS binding.
LY2817412 shows high selectivity versus mu, kappa, and delta opioid receptors was also excellent (Ki > 375 nM).
LY2817412 reduces voluntary alcohol drinking in male and female msP rats.
| M.Wt | 468.92 | |
| Formula | C21H20ClF3N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Miguel A Toledo, et al. J Med Chem. 2014 Apr 24;57(8):3418-29.
2. Kallupi M, et al. Neuropsychopharmacology. 2017 Feb;42(3):695-706.
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