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LY2881835

Chemical Structure : LY2881835

CAS No.: 1292290-38-0

LY2881835 (LY-2881835;LY 2881835)

Catalog No.: PC-60239Not For Human Use, Lab Use Only.

A potent, selective, orally available GPR40 agonist with EC50 of 8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LY2881835 is a potent, selective, orally available GPR40 agonist with EC50 of 8 nM.
    LY2881835 displays no activity against PPARα/β/γ (>10 uM).
    LY2881835 demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.

    Physicochemical Properties

    M.Wt 491.631
    Formula C33H33NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-3-(4-((4-(spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl)oxy)phenyl)hex-4-ynoic acid

    References

    1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916.

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