Chemical Structure : LY2881835
Catalog No.: PC-60239Not For Human Use, Lab Use Only.
A potent, selective, orally available GPR40 agonist with EC50 of 8 nM.
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LY2881835 is a potent, selective, orally available GPR40 agonist with EC50 of 8 nM.
LY2881835 displays no activity against PPARα/β/γ (>10 uM).
LY2881835 demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.
M.Wt | 491.631 | |
Formula | C33H33NO3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916.
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